The mayapple plant or American mandrake is unrelated to the European mandrake, part of the Solanaceae family. European mandrake is a toxic plant with properties similar to belladonna and currently lacks medicinal applications. In Eastern countries, it was supposed to promote human fertility.
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Healing Properties
North American natives have been using podophyllin (the resin of the American mandrake’s root) for ages, and from 1820 onwards, it became part of several pharmaceutical preparations.
Its active component, podophyllotoxin, is an effective but well-tolerated purgative in low doses. It also has cholagogue properties (helps empty the gall bladder).
It has been recently proven that podophyllin has antimitotic properties (prevents cellular division). It has been successfully tested in treating acuminated condyloma acuminatum, papilloma, warts, and other viral tumors of the skin. Its applications in cancer treatment are currently under research.
Warning
In high doses, it can provoke violent diarrhea and even death.
Mayapple Plant Scientific Facts
- Scientific Name – Podophyllum peltatum L.
- Other Names – American mandrake, wild lemon.
- French – Podophylle.
- Spanish – Podófilo.
- Environment – Meadows and damp forests all over the Atlantic regions of North America. It does not grow in Europe.
- Description—The mayapple is an herbaceous plant of the Berberidaceae family that grows up to 50 cm high. Its fruit is aromatic yellow berries.
- Parts of the plant used medicinally – The resin of the root (podophyllin).
How to use Mayapple
- An intake of 0.25 to 0.5 grams of the root, or 50 to 100 mg of podophyllin, results in a regular evacuation 12 hours after the intake.
- Podophyllin resin is applied to the skin in several pharmaceutical preparations. These preparations contain an oil suspension of the resin mixed with paraffin. Put some drops of this suspension on the affected skin area daily to achieve results.
Frequently Asked Question
What are the traditional uses of mayapple?
Historically, Native American tribes used the plant’s root preparations in small doses for various purposes, such as treating skin conditions and intestinal complaints and as a purgative/emetic (to induce vomiting).
Important: These traditional uses don’t guarantee safety or effectiveness and require careful guidance from an expert.
Are there any scientifically studied medicinal uses of mayapple?
Derivatives of podophyllotoxin, the active compound in this plant, are used in FDA-approved treatments:
Topical medications: For genital warts caused by specific strains of the human papillomavirus (HPV)
Cancer therapy: Specific forms of cancer, including testicular cancer, some lymphomas, and lung cancer.
Are there other potential health benefits of mayapple being researched?
Antiviral effects: Early research suggests potential activity against herpes simplex virus (HSV) and possibly other viruses. However, much more study is needed.
Antioxidant properties: Studies hint at potential antioxidant benefits, but research on their impact on human health is limited
How is mayapple used in modern medicine?
The plant itself isn’t directly used. Instead, purified and modified podophyllotoxin derivatives are the basis for prescription medications.
Can I use mayapple root or other plant parts at home for health benefits?
NO. Unprocessed mayapple is toxic. Its improper preparation and use can lead to serious side effects, including life-threatening complications.
Can I take mayapple supplements?
No. Mayapple supplements are not considered safe due to safety concerns. Any product offering direct mayapple benefits is likely dangerous and should be avoided.
Are there any side effects associated with mayapple-derived medications?
Yes, prescription medications containing podophyllotoxin derivatives can cause side effects like nausea, vomiting, hair loss, and nerve damage. Careful medical supervision is essential for their safe use.
Who should NOT use mayapple in any form?
Pregnant women: This plant is hazardous and can cause congenital disabilities or miscarriage.
Individuals with existing medical conditions: Mayapple can interact with numerous medications and worsen certain health conditions. Consultation with a doctor is crucial.
Where can I find reliable information about mayapple?
Reputable medical sources such as:
– National Institutes of Health (NIH): https://www.ncbi.nlm.nih.gov/
– Memorial Sloan Kettering Cancer Center: https://www.mskcc.org/
– Your physician or pharmacist
I’m interested in the therapeutic potential of mayapple. How can I learn more?
Discuss this with your doctor. They can outline the risks, explain ongoing research, and potentially refer you to a specialist working with relevant treatments, if suitable.
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DISCLAIMER: All content on this website is presented solely for educational and informational objectives. Do not rely on the information provided as a replacement for advice, diagnosis, or treatment from a qualified medical expert. If you are pregnant, nursing, or have any preexisting medical concerns, talk to your doctor before using any herbal or natural medicines.
REFERENCES
- George D. Pamplona-Roger, M.D. “Encyclopedia of Medicinal Plants.” George D. Pamplona-Roger, M.D. Encyclopedia of Medicinal Plants. Ed. Francesc X. Gelabert. vols. 2 San Fernando de Henares: Editorial Safeliz, 2000. 517. Print. [mayapple plant]
- Reputable Medical Databases and Resources:
- PubMed (National Institutes of Health): https://pubmed.ncbi.nlm.nih.gov/
- Memorial Sloan Kettering Cancer Center: https://www.mskcc.org/
- Drugs.com https://www.drugs.com/
Last update on 2024-04-21 / Affiliate links / Images from Amazon Product Advertising API